Dr. Adedayo Fodeke

Email Address: aafodeke@oauife.edu.ng; afodeke@yahoo.co.uk

Staff: Academic Staff

Rank in the department: Senior Lecturer

Short Bio, Academic, and Research Activities:

Adedayo Fodeke obtained his PhD from the University of Ibadan, Nigeria in 2005, He was a fellow at the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. His interest is in protein structure and function relationship. To this end, he has concentrated on studying the effect of pH changes on the affinity Ellman’s reagent (5’5-dithiobis (2-nitrobenzoate)) and p-Chloromercuribenzoate for CysF9[93]β sulfhydryl group, as well as kinetics of the reaction of Ellman’s reagent with CysF9[93]β sulfhydryl group in dilute solutions. These reactions have been used as indicators of tertiary and quaternary structure of hemoglobin as well as in the determination of the state of ionization of the ionizable groups in hemoglobins. Reversible affinity of Ellman’s reagent for CysF9[93]β sulfhydryl group is similar to the reversible binding of oxygen to hemoglobin in many respect. Recently, he has taken the studies further by creating an environment which mimics the cellular environment through the use of crowding agent to determine how the effect high activity coefficient can potentially affect the structure and by extension the function of proteins.
He also works on the thermodynamics of the adsorption of toxic dyes and metals from water using agricultural waste materials as a means of getting cheap and efficient adsorbent for water purification.

Office/Room Number: Chemistry Department, Room G20

Area of Specialization: Biophysical Chemistry

Current Research Projects for Postgraduate Students:

1. Effect crowders on the affinity of hemoglobin for Ellman’s reagent
2. Thermodynamics studies of adsorbents from agricultural wastes sources for toxic metals and dyes.

List of Selected Publications (with DOI Number or a Hyperlink):

“Fodeke, A. A., Aboluwoye, C. O and Okonjo, K. O. (2005). Electrostatic effects of ionisablegroups on the reactivity of the CysF9[93]β sulphydryl group in haemoglobins. Ife Journal of Science, 7 (2): 229 – 236. Doi: 10.4314/ijs.v7i2.32181

Okonjo, K. O and Fodeke, A. A. (2006). Reversible reaction of 5,5′-dithiobis(2-nitrobenzoate) with the hemoglobins of the domestic cat: Acetylation of NH3+ terminal group of the β chain transforms complex pH dependence of the forward apparent second order rate constant to a simple form. Biophysical Chemistry, 119 (2): 196 – 204. DOI: 10.1016/j.bpc.2005.09.009

Okonjo, K. O., Fodeke A. A. and Kehinde, A. T. (2006). Reversible reaction of 5,5’-dithiobis(2-nitrobenzoate) with the CysF9[93]β sulfhydryl groups of the hemoglobins of the domestic cat: Variation of the equilibrium and reverse rate constants with pH. Biophysical Chemistry, 121 (1):  65 – 73. doi: 10.1016/j.bpc.2005.12.012

Okonjo, K. O., Adediji A. T., Fodeke, A. A., Adeboye, O. and Ezeh, C. V. (2007). Transition of hemoglobin between two tertiary conformations: Determination of equilibrium and thermodynamic parameters from the reaction of 5,5′-dithiobis(2-nitrobenzoate) with the CysF9[93]β sulfhydryl group. Biophysical Chemistry, 128: 56 – 62. doi: 10.1016/j.bpc.2007.03.008

Fodeke, A. A. and Minton A. P. (2010). Quantitative characterization of polymer-polymer, protein-protein, and polymer-protein interaction via tracer sedimentation equilibrium. Journal of Physical Chemistry B. 114: 10876 – 10880. doi: 10.1021/jp104342f

Fodeke, A. A. and Minton, A. P. (2011). Quantitative characterization of temperature-independent and temperature-dependent protein-protein interactions in highly nonideal solutions. Journal Physical Chemistry B, 115: 11261 – 11268. doi: 10.1021/jp2049266

Fodeke, A. A. and Minton, A. P. (2013). Aldolase in concentrated Ficoll 70 solution: Analysis with Scaled Particle Theory. Ife Journal of Science, 15 (2) 399 – 407. NIGERIA http://ijs.oauife.edu.ng › uploads › Fodeke-and-Minton-18

Okonjo, K. O., Olatunde, A. M., Fodeke, A. A., Babalola, J. O. (2014).  Bohr effect of human           hemoglobin A: Magnitude of negative contributions determined by the equilibrium between two tertiary structures. Biophysical Chemistry, (190–191): 41 – 49. doi: 10.1016/j.bpc.2014.04.002

Fodeke, A. A., Babalola, J. O. and Aboluwoye, C. O.  (2016). Effect of high ionic strength and inositol hexakisphosphate on the reactivity of CysF9[93]β of  rabbit haemoglobin. International Journal of Basic and Applied Sciences, 5 (3): 86 – 95. https://www.semanticscholar.org/paper/Effect-of-High-Ionic-Strength-and-Inositol-on-the-9-Fodeke-Babalola/a98a3d1e736d7b30e7778d024a649054c3190d1e

Fodeke, A. A. (2017). Organic phosphate binding inhibits high pH t-isomerization of the β-chain in straw-coloured fruit bat (Eidolon helvum) haemoglobin. South African Journal of Chemistry, 70: 181 – 188. http://www.scielo.org.za/pdf/sajc/v70/25.pdf

Fodeke, A. A.  (2019). Quantitative characterization of temperature‑independent polymer–polymer interaction and temperature‑dependent protein–protein and protein–polymer interactions in concentrated polymer solutions. European Biophysics Journal, 48(2): 189 – 202. doi: 10.1007/s00249-019-01345-8

Okonjo, K. O., Fodeke, A. A., Atolaiye, O. B., Olatunde, A. M., Ajaelu C. J., Ojelabi, O., Adedeji, A. T., Adebayo, A. M. Uhuo, O. V. and Babalola, J. O. (2019). R and R2 quaternary structures of carbonmonoxyhemoglobins: differential effect of inositol hexaphosphate of their affinity for Ellman’s reagent.  Biophysical Chemistry, 247: 1-12. https://doi.org/10.1016/j.bpc.2019.02.002

Fernandez, C., Fodeke, A. A. and Minton, A. P. (2019). Quantitative characterization of the concentration-dependent interaction between molecules of dextran 70 in aqueous solution: Measurement and analysis in context of thermodynamic and compressible sphere      models. Biopolymers, 110(5):1-6; e23284. doi: 10.1002/bip.23284

Fodeke, A. A and Olayera, O. O (2019). Thermodynamics of adsorption of malachite green hydrochloride on treated and untreated corncob charcoal. Jornal of Serbian Chemical Society, 84(10): 1143 – 1154. DOI: https://doi.org/10.2298/JSC190209042F

Ogunmoyole, T., Fodeke, A. A. and Adewale, I. O. (2019). Denaturation studies of Clarias gariepinus glutathion transferase in dilute and crowded solutions European Biophysics Journal, 48(8): 789 – 801. doi: 10.1007/s00249-019-01405-z

Ogunmoyole, T., Adewale, I. O, Fodeke, A. A. and Afolayan A. (2020). Catalytic studies of glutathione transferase from Clarias gariepinus (Burchell) in dilute and crowded solutions. Comparative Biochemistry and Physiology, Part C, (228) 108648: 1 – 13. doi: 10.1016/j.cbpc.2019.108648

Fodeke, A. A and Ayejuyone, O. J (2021). Adsorption of methelene blue on corncob charcoal: Thermodynamic studies. Ife Journal of Science, 23 (1): 131 – 144. Doi: 10.4314/ijs.v23i1.13

Fodeke, A. A (2022). Thermodynamic studies of congo red adsorption: Avoiding erroneous conclusions from use of isotherm models. Journal of Dispersion Science and Technology. doi.org/101080/1932691.2022.2154226

Google Scholar and/ Scopus Link(s): https://scholar.google.com/citations?user=yE1T9xMAAAAJ&hl=en