Dr. Olatomide Fadare

Lecturer 1

Email Address: tofadare@oauife.edu.ng

Staff: Academic Staff

Rank in the department: Senior Lecturer

Short Bio, Academic, and Research Activities:

I am a medicinal chemist with basic training in Organic Synthesis with skills in computational chemistry and biological testing and interested in the design and development of new therapeutic agents by synthesis of heterocyclic scaffolds that may be substituted at various positions by different groups to create an array of compounds which may be screened for any particular pharmacological activity, in-silico, in-vitro or in-vivo with the aim of identifying a lead molecule which may be further optimized by synthetic modification. Diseases of interest are infectious diseases (Malaria and COVID-19) and Central Nervous System disorders (Depression and Alzheimers Disease).

Office/Room Number: CH112, Organic Research Lab

Area of Specialization: Medicinal Chemistry

Current Research Projects for Postgraduate Students:

(1) Synthesis and Computational Study of Optimized Pharmacophores of the Plasmodium falciparum Formate Nitrite Transporter (PfFNT) as potential antimalarial agents.
(2) Antimalaria Study of Novel Semi-synthetic Indole Derivatives Fused to Sterol Scaffolds.
(3) Synthesis and Computational Study of Fused Indenoimidazole Derivatives as Potential Plasmodium falciparum Trasnketolase Inhibitors – A Malaria Drug Discovery Effort.
(4) Computer aided design and synthesis of Sialylglycoconjugates of Biginelli adducts of 1-(3-hydroxyquinoxalin-2-yl)-3-methyl-1H-pyrazol-5(4H)-one as COVID-19 Curatives

List of Selected Publications (with DOI Number or a Hyperlink): Ouzebla, D., Ourhriss, N., Fadare, O. A., Belghiti, M. E., El Abdallaoui, H. E. and Zeroual A. (2022). Efficient Synthesis of Acyclic Nucleosides by N-Alkylation Using K2CO3 Supported with Natural Phosphate (K2CO3@NP) as Catalyst and Docking Study Against VIH. Chemistry Africa. https://link.springer.com/article/10.1007/s42250-022-00528-9

Mehta, J., Utkarsh, K., Fuloria, S., Singh, T., Sekar, M., Salaria, D., Rolta, R., Begum, M. Y., Gan, S. H., Rani, N. N. I. M., Chidambaram, K., Subramaniyan, V., Sathasivam, K. V., Lum, P. T., Uthirapathy, S., Fadare, O. A., Awofisayo, O. and Fuloria, N. K. (2022). Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In-Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections. Molecules 2022, 27, 4971. https://www.mdpi.com/1420-3049/27/15/4971

Egharevba, G. O., Kamal, A., Dosumu, O. O., Routhu, S., Fadare, O. A., Oguntoye S. O., Njinga, S. N. and Oluyori, A. P., (2022). Synthesis and Characterization of Novel Combretastatin Analogues of 1,1-diaryl vinyl sulfones, with Antiproliferative Potential via In-silico and In-vitro Studies. Scientific Reports, 12, 1901. DOI: 10.1038/s41598-022-05958-6

Salaria, D., Rolta, R., Mehta, J., Awofisayo, O., Kaur, B., Kumar, B., da Costa R. A., Chandel, S. R., Kaushik, N., Choi, E. H. and Kaushik, N. K. (2022). Phytoconstituents of Traditional Himalayan Herbs as Potential Inhibitors of Human Papillomavirus (HPV-18) for Cervical Cancer Treatment: An In-silico Approach. PLoS One, 17(3), e0265420. DOI: 10.1371/journal.pone.0265420

Fadare O.A., Omisore, N. O., Adegbite, O. B., Awofisayo, O. A., Ogundolie, F. A., Adesanwo, J. K. and Obafemi, C. A. (2021). Structure Based Design, Stability Study and Synthesis of the Dinitrophenylhydrazone Derivative of the Oxidation Product of Lanosterol as a Potential P. falciparum Transketolase Inhibitor and In-vivo Antimalarial Study. In Silico Pharmacology, 9(1), 38. DOI: 10.1007/s40203-021-00097-8

Tabrizi, L., Olasunkanmi, L. O. and Fadare, O. A. (2020). De novo Design of Thioredoxin Reductase-Targeted Heterometallic Titanocene–Gold Compounds of Chlorambucil for Mechanistic Insights into Renal Cancer. Chemical Communications, 56, 297-300. DOI: 10.1039/C9CC07406F

Google Scholar and/ Scopus Link(s): https://scholar.google.com/citations?hl=en&user=SKwi5JEAAAAJ&view_op=list_works&sortby=pubdate
https://www.researchgate.net/profile/Olatomide-Fadare-2